Hito 200K del Protein Data Bank

Hola,

a punto de empezar el congreso PAG30, empezamos el año con una buena noticia: 

 

Pego aquí la reseña oficial del Protein Data Bank: 

Date: Wed, 11 Jan 2023 09:55:41 -0500
Subject: pdb-l: PDB Reaches a New Milestone: 200,000+ Entries

With this week's update, the PDB archive contains a record 200,069 
entries. The archive passed 150,000 structures in 2019 and 
100,000 structures in 2014. 

Established in 1971, this central, public archive has reached this 
critical milestone thanks to the efforts of structural biologists 
throughout the world who contribute their experimentally-determined 
protein and nucleic acid structure data.

wwPDB data centers support online access to three-dimensional structures 
of biological macromolecules that help researchers understand many 
facets of biomedicine, agriculture, and ecology, from protein synthesis 
to health and disease to biological energy. Many milestones have been 
reached since the archive released the 100,000th structure in 2014. PDB 
data have been seminal in understanding SARS-CoV-2, and provided the 
foundation for the development of AI/ML techniques for predicting 
protein structure. The 50th anniversary of the PDB was celebrated 
throughout 2021 <https://www.wwpdb.org/pdb50>.

Today, the archive is quite large, containing more than 3,000,000 files 
related to these PDB entries that require more than 1086 Gbytes of 
storage. PDB structures contain more than 1.8 billion non-hydrogen atoms.


Function follows form
In the 1950s, scientists had their first direct look at the structures 
of proteins and DNA at the atomic level. Determination of these early 
three-dimensional structures by X-ray crystallography ushered in a new 
era in biology-one driven by the intimate link between form and 
biological function. As the value of archiving and sharing these data 
were quickly recognized by the scientific community, the Protein Data 
Bank (PDB) was established as the first open access digital resource in 
all of biology by an international collaboration in 1971 with data 
centers located in the US and the UK.

Among the first structures deposited in the PDB were those of myoglobin 
and hemoglobin, two oxygen-binding molecules whose structures were 
elucidated by Chemistry Nobel Laureates John Kendrew and Max Perutz. 
With this week's regular update, the PDB welcomes 266 new structures 
into the archive. These structures join others vital to drug discovery, 
bioinformatics and education.

The PDB is growing rapidly, increasing in size ~13% since 2011. In 2022, 
an average of 275 new structures were released to the scientific 
community each week. The resource is accessed hundreds of millions of 
times annually by researchers, students, and educators intent on 
exploring how different proteins are related to one another, to clarify 
fundamental biological mechanisms and discover new medicines.

Twenty Years of Collaboration
Since its inception, the PDB has been a community-driven enterprise, 
evolving into a mission critical international resource for biological 
research. The wwPDB partnership was established in July 2003 with PDBe, 
PDBj, and RCSB PDB. Today, the collaboration includes partners BMRB 
(joined in 2006) and EMDB (2021).

The wwPDB ensures that these valuable PDB data are securely stored, 
expertly managed, and made freely available for the benefit of 
scientists and educators around the globe. wwPDB data centers work 
closely with community experts to define deposition and annotation 
policies, resolve data representation issues, and implement community 
validation standards. In addition, the wwPDB works to raise the profile 
of structural biology with increasingly broad audiences.

Each structure submitted to the archive is carefully curated by wwPDB 
staff before release. New depositions are checked and enhanced with 
value-added annotations and linked with other important biological data 
to ensure that PDB structures are discoverable and interpretable by 
users with a wide range of backgrounds and interests.

wwPDB eagerly awaits the next 100,000 structures and the invaluable 
knowledge these new data will bring.

Hasta pronto,

Bruno